Progestins Activate the AKT Pathway in Leiomyoma Cells and Promote Survival
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چکیده
منابع مشابه
Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235
Retinoblastoma is a pediatric cancer of the retina most often caused by inactivation of the retinoblastoma (RB1) tumor suppressor gene. We previously showed that Rb1 loss cooperates with either co-activating the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, or co-deleting Pten, to initiate retinoblastoma tumors in mice. The objectives of this study were to determine if the AKT pathway is ac...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2009
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend.23.4.9996